Hydrochloric Acid → 4-(2,4-Difluorophenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxylic acid

온도

60 °C

To a suspension of methyl 4-(2,4-difluorophenyl)-2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)-1,3-thiazole-5-carboxylate (250 mg, 0.649 mmol) obtained above in THF (5 mL) and MeOH (5 mL), was added 2N aqueous solution of sodium hydroxide (1 mL) and the mixture was stirred for 2 h at 60° C. To the mixture, was added a 2:1 mixture of EtOAc and THF (60 mL) and 1N hydrochloric acid. The organic layer was separated and the aqueous layer was extracted with a 2:1 mixture of EtOAc and THF (10 mL). The combined organic layers were washed with brine (5 mL) and then dried over anhydrous sodium sulfate. Insoluble materials were removed by filtration and the filtrate was concentrated under reduced pressure to obtain title compound (225 mg, 93%) as a pale yellow solid.

1. additionTo the mixture, was added
2. customThe organic layer was separated
3. extractionthe aqueous layer was extracted with a 2:1 mixture of EtOAc and THF (10 mL)
4. washThe combined organic layers were washed with brine (5 mL)
5. dry with materialdried over anhydrous sodium sulfate
6. customInsoluble materials were removed by filtration
7. concentrationthe filtrate was concentrated under reduced pressure

ORD 기록

ord-4b50f22cd7ef4d9ebcd9b59d64b9b3ff

출처 데이터셋

uspto-grants-2015_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09090601B2