Hydrogen Bromide → HCID 19908238, 화합물
반응식
C1(C)C=CC(S([N:10]2[CH2:18][C:17]3[CH2:16][NH:15][CH2:14][CH2:13][C:12]=3[CH2:11]2)(=O)=O)=CC=1.O.[BrH:21]>C1(O)C=CC=CC=1>[BrH:21].[BrH:21].[C:17]12[CH2:18][NH:10][CH2:11][C:12]=1[CH2:13][CH2:14][NH:15][CH2:16]2참가 물질
5
실험 절차
1.5 g of N8 -(p-toluenesulfonyl)-3,8-diazabicyclo[4.3.0]non-1(6)-ene, prepared in Preparation 8, was suspended in 15 ml of 48% hydrobromic acid and 2 g of phenol, and the reaction mixture was refluxed for 4 hours. After cooling the reaction mixture, 20 ml of water was added. The mixture was washed with chloroform (40 ml×3). The aqueous phase was taken and decolorized by active carbon. The aqueous phase was concentrated under reduced pressure and thus resulting solid was washed with 1:1 methanol-ethylether solvent. 0.9 g of the title compound was obtained (yield 98%).
후처리
- additionwas added
- washThe mixture was washed with chloroform (40 ml×3)
- concentrationThe aqueous phase was concentrated under reduced pressure
- customthus resulting solid
- washwas washed with 1:1 methanol-ethylether solvent
출처 및 근거
- ORD 기록
- ord-f81025daa64b4df2b56f60455007b987
- 출처 데이터셋
- uspto-grants-1992_02
- 특허 번호
- US05089621
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