Hydrochloric Acid → Ketorolac

HRID 1534756

반응식

HRID 1534756 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1.C(O)C(N)(CO)CO.C(N(CC([O-])=O)CC(O)=O)CN(CC([O-])=O)CC(O)=O.[Na+].[Na+].NC(CO)(CO)CO.C(OC(C)C)(=O)CCCCC(OC(C)C)=O.Cl>O.C(O)(C)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 6503Tris(hydroxymethyl)aminomethane3회HCID 8759EDTA disodium saltHCID 23368Diisopropyl AdipateHCID 84003Ketorolac Tromethamine2회

생성물 1

HCID 3826Ketorolac수율 1%

시약·촉매·용매 2

HCID 962Water용매2회HCID 3776Isopropanol용매

실험 절차

The above 1.0% ketorolac topical gel formulation was prepared by dissolving the ketorolac tromethamine, EDTA disodium salt and tromethamine in purified water to form an aqueous solution. (Tromethamine was added to maintain the pH of the formulation at pH 4.2±0.2.) The diisopropyl adipate and butylated hydroxytoluene were then dissolved in the isopropyl alcohol to form an alcoholic solution. Carbomer 940 was then slowly dispersed in this alcoholic solution so as to avoid gelling. After the carbomer 940 was completely dispersed, the aqueous solution containing ketorolac tromethamine was then added to the alcoholic solution. The resulting mixture was then brought up to weight with purified water and, if needed, the pH was adjusted with either tromethamine or hydrochloric acid to maintain the pH of the formulation at 4.2±0.2. The resulting formulation was then slowly stirred at temperatures below 20° C. until gelling of the formulation was complete.

후처리

  1. customto form an aqueous solution
  2. temperatureto maintain the pH of the formulation at pH 4.2±0.2
  3. customto form an alcoholic solution
  4. additionwas then added to the alcoholic solution
  5. temperatureto maintain the pH of the formulation at 4.2±0.2

출처 및 근거

ORD 기록
ord-7e38d66fcc8e495a8f044f1f0a090c94
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05091182

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