Hydrochloric Acid → N-(2-(1H-Indene-1-yl)ethyl)hydroxylamine

HRID 1534796노트

반응식

HRID 1534796 반응식
[CH:1]1([CH2:10][CH:11]=[N:12][OH:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C([BH3-])#N.[Na+].CN(C1C=CC(N=NC2C=CC(S(O)(=O)=O)=CC=2)=CC=1)C.Cl.[NH4+].[OH-]>CO.O>[CH:1]1([CH2:10][CH2:11][NH:12][OH:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 11037Benzenesulfonic acid, 4-(2-(4-(dimethylamino)phenyl)diazenyl)-HCID 14923Ammonium HydroxideHCID 5003444Sodium cyanoborohydrideHCID 856179012-(1H-indene-1-yl)acetaldoxime

생성물 1

HCID 19908298N-(2-(1H-Indene-1-yl)ethyl)hydroxylamine

시약·촉매·용매 2

HCID 887Methanol용매2회HCID 962Water용매

실험 절차

2-(1H-indene-1-yl)acetaldoxime (50 mg, 0.29 mmol) was dissolved in methanol (15 ml) and treated with sodium cyanoborohydride (34 mg, 0.54 mmol). Methyl orange indicator (ca 1 mg) was added, and the pH of the mixture adjusted by addition of 1:1 conc. HCl:MeOH to maintain the indicator color slightly to the red side of the turning point. After ca 1 ml of the acid mixture had been added, the indicator remained red. The reaction was made basic with conc. NH4OH, and water was added. The mixture was extracted with ether and the ether layer was dried over sodium sulfate, filtered, and evaporated to dryness in vacuo to provide N-(2-(1H-indene-1-yl)-ethyl)hydroxylamine.

후처리

  1. additionwas added
  2. extractionThe mixture was extracted with ether
  3. dry with materialthe ether layer was dried over sodium sulfate
  4. filtrationfiltered
  5. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-cdeca3a901b44f63bdb2a148663f4a0f
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05091387

반응 노트

불러오는 중…