Dimethylformamide → 4-Bromo-1,1-dimethoxybutane

HRID 1576170노트

반응식

HRID 1576170 반응식
[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH2:4][CH2:5][CH2:6]O.CN(C)C=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:35]>O>[CH3:1][O:2][CH:3]([O:8][CH3:9])[CH2:4][CH2:5][CH2:6][Br:35]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 899884,4-Dimethoxybutan-1-ol

생성물 1

HCID 104202254-Bromo-1,1-dimethoxybutane

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 0.1 moles of 4,4-dimethoxybutanol in 50 ml. of dimethylformamide containing 0.1 moles of triphenylphosphine is allowed to react for 18 hours with 0.1 moles of carbon tetrabromide. The mixture is diluted with water and extracted with ether. The ether extracts are combined, washed with water, dried and evaporated to a crude product which is purified by distillation to yield 4,4-dimethoxybutylbromide. This bromide is then converted into the diethyl phosphonate using the procedure described in Example 2.

후처리

  1. extractionextracted with ether
  2. washwashed with water
  3. customdried
  4. customevaporated to a crude product which
  5. distillationis purified by distillation

출처 및 근거

ORD 기록
ord-2504079ee5c946529545f5211e70f594
출처 데이터셋
uspto-grants-1976_09
특허 번호
US03979458

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