Potassium Hydroxide → 2-Methyl-1-phenyl-1-propanol

HRID 1578039

반응식

HRID 1578039 반응식
Cl([O-])(=O)(=O)=O.[OH-].[K+].[C:8]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:12])[CH:9]([CH3:11])[CH3:10]>C(O)(C)C.N#N>[C:13]1([CH:8]([CH:9]([CH3:11])[CH3:10])[OH:12])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 69144IsobutyrophenoneHCID 123351Perchlorate

생성물 1

HCID 956262-Methyl-1-phenyl-1-propanol

시약·촉매·용매 2

HCID 947Nitrogen용매HCID 3776Isopropanol용매2회

실험 절차

12.2 mg (2×10-5 moles) of [Ir(PPEI)COD]+ClO4- (+) were suspended in 50 ml of isopropanol and oxidized with air for 4 hours. The resulting yellow solution was then degasified at reflux for 20 minutes in a nitrogen flow and successively treated with 4.4 ml of a deaerated isopropanol solution of KOH (4 mg of KOH), effecting a preliminary reduction for 30 minutes at reflux in N2. 3.0 ml of deaerated isobutyrophenone was then added to the solution. After 120 minutes a conversion to phenylisopropylcarbinol (+) of 92.1% with an e.e. of 13% was obtained. Ratios:

후처리

  1. temperatureat reflux for 20 minutes in a nitrogen flow
  2. customfor 30 minutes

출처 및 근거

ORD 기록
ord-6c126e5f0d3a482d9d400750927ae2b4
출처 데이터셋
uspto-grants-1981_09
특허 번호
US04290961

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