Sodium Hydroxide → 7-(Pyridin-3-yl)heptan-1-amine

HRID 1583422노트

반응식

HRID 1583422 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)C)[CH:2]=1.[OH-].[Na+]>Cl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 13557529N-[7-(Pyridin-3-yl)heptyl]acetamide

생성물 1

HCID 135575307-(Pyridin-3-yl)heptan-1-amine수율 81.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 5.1 g of N-[7-(3-pyridyl)heptyl]acetamide was heated to reflux in diluted hydrochloric acid overnight. The mixture was cooled, made basic with 50% sodium hydroxide solution and was extracted with dichloromethane. The combined organic layers were dried over potassium carbonate and were evaporated. The residue was distilled to give 3.4 g of 3-pyridine heptanamine, bp 175°-180° C./0.4 mm.

후처리

  1. temperatureThe mixture was cooled
  2. extractionwas extracted with dichloromethane
  3. dry with materialThe combined organic layers were dried over potassium carbonate
  4. customwere evaporated
  5. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-3805197ade654298a29bb3b30b38035f
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04551460

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