Iodoethane → HCID 18600216, 화합물

HRID 1583568

반응식

HRID 1583568 반응식
[CH3:1][C@H:2]([N:6]1CCC[C:7]1=[O:11])[C:3]([OH:5])=[O:4].C(I)C.[CH2:15]([S:22]CBr)[C:16]1[CH:21]=[CH:20]C=[CH:18][CH:17]=1>>[CH2:21]([C:16]1([CH2:15][SH:22])[CH2:17][CH2:18][N:6]([C@@H:2]([CH3:1])[C:3]([OH:5])=[O:4])[C:7]1=[O:11])[CH3:20]

참가 물질

4

반응물 3

HCID 6340IodoethaneHCID 4067177BenzylthiobromomethaneHCID 7175678(S)-2-(2-oxopyrrolidin-1-yl)propanoic acid

생성물 1

HCID 18600216HCID 18600216, 화합물

실험 절차

Following the procedures of Examples 1C-1E, α(S)-methyl-2-oxo-1-pyrrolidineacetic acid was first alkylated with ethyl iodide and then with benzylmercaptomethyl bromide. Removal of the benzyl group in the usual way and purification by chromatography provided the title compound as a mixture of diastereomers. [α]D25 =-4.04° (c=1, methanol).

후처리

  1. customRemoval of the benzyl group
  2. customin the usual way and purification by chromatography

출처 및 근거

ORD 기록
ord-f5282b269af4496fb176721b5249d416
출처 데이터셋
uspto-grants-1985_11
특허 번호
US04552889

연결된 노트

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