Acetic Anhydride → N-[(6-Methoxypyridin-2-yl)methyl]acetamide
반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)#[N:2].[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C>[Ni]>[C:11]([NH:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)(=[O:13])[CH3:12]참가 물질
5
실험 절차
A mixture of 1.0 g (7.46 mmole) of 2-cyano-6-methoxypyridine, 0.37 g (4.48 mmole) of sodium acetate, 25 ml of acetic anhydride and about 1.0 g of Raney nickel was hydrogenated on a Parr apparatus for about 5.5 hours. The mixture was filtered, and then evaporated with warming in vacuo to provide 2-acetamidomethyl-6-methoxypyridine. The structural assignment was supported by infrared spectral analysis.
후처리
- filtrationThe mixture was filtered
- customevaporated
- temperaturewith warming in vacuo
출처 및 근거
- ORD 기록
- ord-0c3659fc96d14b36940feb62517e1d91
- 출처 데이터셋
- uspto-grants-1985_11
- 특허 번호
- US04555573
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