Carbon tetrabromide → 4-(Bromomethyl)benzene-1,2-dicarbonitrile

HRID 1585936노트

반응식

HRID 1585936 반응식
O[CH2:2][C:3]1[CH:4]=[C:5]([C:11]#[N:12])[C:6](=[CH:9][CH:10]=1)[C:7]#[N:8].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(Br)(Br)(Br)[Br:33]>C1COCC1>[Br:33][CH2:2][C:3]1[CH:4]=[C:5]([C:11]#[N:12])[C:6](=[CH:9][CH:10]=1)[C:7]#[N:8]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18779681HCID 18779681, 화합물

생성물 1

HCID 187797764-(Bromomethyl)benzene-1,2-dicarbonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Hydroxymethyl-phthalonitrile from step 2 (1.3 g, 8.2 mmol) was dissolved in THF (41 ml) and treated with Ph3P (3.2 g, 12.3 mmol) followed by CBr4 (4 g, 12.3 mmol). The reaction mixture was stirred at room temp. for 21 hours. The solvent was removed in vacuo and the residue purified by flash chromatography (15% EtOAc/Hexane) to yield the desired product. FAB MS: 222 m/z (M+ +H)

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue purified by flash chromatography (15% EtOAc/Hexane)

출처 및 근거

ORD 기록
ord-54025b39475040fbb0c53cd9b00fe561
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05939439

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