Ammonium Hydroxide → 1-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline

HRID 1586150

반응식

HRID 1586150 반응식
[CH2:1]([N:3]1[C:7]([NH:8][C:9]2[C:10](=[CH:14][CH:15]=[C:16]([N+:18]([O-:20])=[O:19])[CH:17]=2)[C:11](O)=O)=[CH:6][CH:5]=[N:4]1)[CH3:2].[NH4+].[OH-].O=P(Cl)(Cl)[Cl:25]>>[CH2:1]([N:3]1[C:7]2=[N:8][C:9]3[C:10]([C:11]([Cl:25])=[C:6]2[CH:5]=[N:4]1)=[CH:14][CH:15]=[C:16]([N+:18]([O-:20])=[O:19])[CH:17]=3)[CH3:2]

참가 물질

4

반응물 3

HCID 14923Ammonium HydroxideHCID 24813Phosphorus oxychlorideHCID 21217705N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid

생성물 1

HCID 543387961-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline수율 82%

실험 절차

A mixture of N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid (3.4 g, 12.32 mmol) and POCl3 (20 ml) is refluxed for 8 hours. The reaction mixture is poured into ice waterl, neutralized with concentrated NH4OH, and the resulting solid is collected by filtration,washed with water and dried to afford 2.8 g (82%) of 1-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline.

후처리

  1. temperatureis refluxed for 8 hours
  2. additionThe reaction mixture is poured into ice waterl
  3. filtrationthe resulting solid is collected by filtration,washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-ebf142312dc747bd91960e42e40c6e6d
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05942520

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