4-Chlorophenyl Isocyanate → N-(4-chlorophenyl)-N'-1-propanesulfonylurea

HRID 1586840

반응식

HRID 1586840 반응식
[CH2:1]([S:4]([NH2:7])(=[O:6])=[O:5])[CH2:2][CH3:3].[OH-].[Na+].[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:18]=[O:19])=[CH:13][CH:12]=1>CC(C)=O>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:7][S:4]([CH2:1][CH2:2][CH3:3])(=[O:6])=[O:5])=[O:19])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 76934-Chlorophenyl IsocyanateHCID 14798Sodium HydroxideHCID 3401849Propane-1-sulphonamide

생성물 1

HCID 22131290N-(4-chlorophenyl)-N'-1-propanesulfonylurea수율 64.1%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

Procedure A was followed with 1-propanesulfonamide (5.0 g, 40.6 mmole), in acetone (40 ml), and 1.0N sodium hydroxide (40.6 ml). After ten minutes of stirring, 4-chlorophenyl isocyanate (6.2 g, 40.6 mmole) dissolved in about 40 ml of acetone was added over a five minute period. The mixture was allowed to stir for about two hours and filtered. The filtered solid was washed with water which dissolved most of it. 1N HCl (40 ml) was added to the combined filtrates and the resulting precipitate was filtered off and dried at about 65° C. under vacuum to provide 7.2 g of product.

후처리

  1. additionwas added over a five minute period
  2. stirringto stir for about two hours
  3. filtrationfiltered
  4. washThe filtered solid was washed with water which
  5. dissolutiondissolved most of it
  6. addition1N HCl (40 ml) was added to the combined filtrates
  7. filtrationthe resulting precipitate was filtered off
  8. customdried at about 65° C. under vacuum

출처 및 근거

ORD 기록
ord-579f1a0c6db44bd1a68d9bc7afbe0a55
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216026

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