Acetyl bromide → 4-Bromo-6,6'-dimethyl-2,2'-bipyridine

HRID 1586927노트

반응식

HRID 1586927 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([N+]([O-])=O)[CH:5]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[N+:7]=1[O-].[OH-].[Na+].C([Br:24])(=O)C>P(Br)(Br)Br>[Br:24][C:4]1[CH:3]=[C:2]([CH3:1])[N:7]=[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[N:10]=2)[CH:5]=1

참가 물질

5

반응물 3

HCID 10482Acetyl bromideHCID 14798Sodium HydroxideHCID 110321326,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide

생성물 1

HCID 118322434-Bromo-6,6'-dimethyl-2,2'-bipyridine

시약·촉매·용매 1

HCID 24614Phosphorus tribromide용매

실험 절차

6,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide (0.50 g, 2.0 mmoles) was dissolved in acetyl bromide (10.0 ml) and phosphorus tribromide (2.5 ml). After refluxing for 1.5 hours the mixture was poured into 100 g ice and the solution was neutralized with 30% sodium hydroxide solution. The mixture was extracted with chloroform, the chloroform phase was dried and evaporated. The product was purified by means of flash chromatography.

후처리

  1. temperatureAfter refluxing for 1.5 hours the mixture
  2. extractionThe mixture was extracted with chloroform
  3. dry with materialthe chloroform phase was dried
  4. customevaporated
  5. customThe product was purified by means of flash chromatography

출처 및 근거

ORD 기록
ord-1c109e159f09407a99c521bc04376b94
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216134

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