Hydrochloric Acid → 2-Diphenylphosphorylamino-4-trichloromethylpyridine

HRID 1587008노트

반응식

HRID 1587008 반응식
[C:1]1([P:7](Cl)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:16][C:17]1[CH:22]=[C:21]([C:23]([Cl:26])([Cl:25])[Cl:24])[CH:20]=[CH:19][N:18]=1.Cl>>[C:1]1([P:7]([NH:16][C:17]2[CH:22]=[C:21]([C:23]([Cl:25])([Cl:24])[Cl:26])[CH:20]=[CH:19][N:18]=2)([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 73910Diphenylphosphinic chlorideHCID 137101174-(Trichloromethyl)pyridin-2-amine

생성물 1

HCID 197603922-Diphenylphosphorylamino-4-trichloromethylpyridine수율 56.7%

실험 절차

6.2 ml (0.03 mol) of diphenylphosphoryl chloride were added to 6.3 g (0.03 mol) of 2-amino -4trichloromethylpyridine and 60 ml of pryidine at 0° C. After 12 hours at 25° C., the reaction mixture was added to 200 ml of 5% strength hydrochloric acid. The colorless precipitate formed was isolated. 7.0 g (53%) of the desired product were obtained. Mp.: 134°-136° C.; Active Ingredient Example 1.016

후처리

  1. customThe colorless precipitate formed
  2. customwas isolated

출처 및 근거

ORD 기록
ord-f4d77332f8ca4055bb4724aa2dbf5172
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216171

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