2-Pyrrolidone → 1-[3-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone

HRID 15878

반응식

HRID 15878 반응식
Br[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16]>>[OH:10][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][C:12]2=[O:16])[CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 120252-PyrrolidoneHCID 27340902-(3-Bromophenyl)ethan-1-ol

생성물 1

HCID 574443611-[3-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone수율 15%

실험 절차

The title compound was prepared in 15% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 2-(3-bromophenyl)ethanol and 2-pyrrolidinone. Purification was achieved by flash chromatography on silica gel eluting with ethyl acetate.

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-bbab621c1e3b4c94b45ab537ff5a5d8b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732600B2

연결된 노트

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