Carbon tetrabromide → HCID 20076910, 화합물

HRID 1588721노트

반응식

HRID 1588721 반응식
[C:1]([Br:5])(Br)(Br)[Br:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[NH:25]1[CH:29]=[CH:28][N:27]=[C:26]1[CH:30]=O>C(Cl)Cl>[Br:2][C:1]([Br:5])=[CH:30][C:26]1[NH:25][CH:29]=[CH:28][N:27]=1

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 249551H-imidazole-2-carbaldehyde

생성물 1

HCID 20076910HCID 20076910, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

반응 조건

온도
0 °C

실험 절차

Mix carbon tetrabromide (49.8 g, 150 mmol) and methylene chloride (75 mL) and cool to 0° C. Add, by dropwise addition, a solution of triphenylphosphine (78.6 g, 300 mmol) in methylene chloride (75 mL). Stir at 0° C. for 30 minutes. Add, by dropwise addition, a solution of 2-imidazole-carboxaldehyde (7.57 g, 78.8 mmol) in methylene chloride (75 mL). Remove the cooling bath and stir at room temperature until the reaction is complete. Pour onto ethyl ether and water, separate the organic layer and dry (MgSO4). Filter and evaporate the solvent in vacuo. Purify by silica gel chromatography to yield the title compound.

후처리

  1. additionAdd, by dropwise addition
  2. additionAdd, by dropwise addition
  3. customRemove the cooling bath
  4. stirringstir at room temperature until the reaction
  5. additionPour onto ethyl ether and water
  6. customseparate the organic layer
  7. dry with materialdry (MgSO4)
  8. filtrationFilter
  9. customevaporate the solvent in vacuo
  10. customPurify by silica gel chromatography

출처 및 근거

ORD 기록
ord-aff6823a6cdf4ba9812c328ef6a8f662
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223518

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