Hydrochloric Acid → (RS)-Clopidogrel

HRID 1590780

반응식

HRID 1590780 반응식
Cl.[S:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH2:7][CH2:8][NH:9][CH:10]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Cl:21])[C:11]([O:13][CH3:14])=[O:12].[CH2:22]=O>C(Cl)Cl>[S:2]1[C:3]2[CH2:7][CH2:8][N:9]([CH:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[Cl:21])[C:11]([O:13][CH3:14])=[O:12])[CH2:22][C:4]=2[CH:5]=[CH:6]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 10223136Methyl [2-(2-thienyl)ethylamino](2-chlorophenyl)acetate

생성물 1

HCID 2806(RS)-Clopidogrel

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

35 g of the hydrochloride of racemic methyl alpha-(2-thienylethylamino)(2-chlorophenyl)acetate are suspended in 150 ml of a 30% (w/w) aqueous solution of formaldehyde. The mixture is kept at 50° C. for 2 hours and then poured, at about 20° C., into 200 ml of methylene chloride. The organic phase is concentrated and the residual oil is dissolved in 120 ml of isopropyl ether in which the hydrochloride is prepared as before; 29.5 g are obtained.

후처리

  1. concentrationThe organic phase is concentrated
  2. dissolutionthe residual oil is dissolved in 120 ml of isopropyl ether in which the hydrochloride
  3. customis prepared as before
  4. custom29.5 g are obtained

출처 및 근거

ORD 기록
ord-f5c9992b4803468f97c3f790d71a0507
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204469

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