Chloroacetone → 2-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester

반응식

Cl[CH2:2][C:3](=[O:5])[CH3:4].[C:6]([C:12]([O:14][CH3:15])=[O:13])#[C:7][C:8](OC)=[O:9].[SH-:16].[Na+]>>[C:3]([C:2]1[S:16][C:6]([C:12]([O:14][CH3:15])=[O:13])=[CH:7][C:8]=1[OH:9])(=[O:5])[CH3:4]

참가 물질

반응물 3

HCID 6571Chloroacetone

HCID 12980Dimethyl acetylenedicarboxylate

HCID 28015Sodium hydrosulfide

생성물 1

HCID 106080802-Thiophenecarboxylic acid, 5-acetyl-4-hydroxy-, methyl ester

실험 절차

According to the description in Synth. Commun., 1996, 26, 1083, methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was synthesized with chloroacetone, dimethyl acetylene dicarboxylate and sodium hydrosulfide as starting materials (yield: 60%).

출처 및 근거

ORD 기록: ord-ecc73145941641afa70ccfc6f141ecaa
출처 데이터셋: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07291449B2

반응 노트

불러오는 중…