Sodium Thiosulfate → 4-(2-Butynyloxy)-6-methanesulfonylpyrimidine

HRID 1592244

반응식

HRID 1592244 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[C:10](SC)[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4].Cl[C:15]1C=CC=C(C(OO)=O)C=1.[S:25]([O-:29])([O-])(=[O:27])=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[CH2:1]([O:5][C:6]1[CH:11]=[C:10]([S:25]([CH3:15])(=[O:29])=[O:27])[N:9]=[CH:8][N:7]=1)[C:2]#[C:3][CH3:4]

참가 물질

5

반응물 3

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 225998774-(2-Butynyloxy)-6-methylthiopyrimidine

생성물 1

HCID 225998634-(2-Butynyloxy)-6-methanesulfonylpyrimidine

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

To 14 ml of chloroform were added 4-(2-butynyloxy)-6-methylthiopyrimidine and 3.5 g of m-chloroperbenzoic acid (>65%), followed by stirring at 0° C. for 10 hours. The reaction mixture was then poured into a saturated aqueous sodium thiosulfate solution and extracted three times with chloroform. The chloroform layers were combined, washed with water, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 1.4 g of 4-(2-butynyloxy)-6-methanesulfonylpyrimidine.

후처리

  1. extractionextracted three times with chloroform
  2. washwashed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f3a961b0cac748c6adc58b759eb1d938
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07291730B2

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