Hydrochloric Acid → 3-(4-Fluorophenyl)-2,2-dimethylpropanoic acid

HRID 1592331노트

반응식

HRID 1592331 반응식
C([O:3][C:4](=[O:16])[C:5]([CH3:15])([CH3:14])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)C.[OH-].[Na+].Cl>O>[F:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C:5]([CH3:15])([CH3:14])[C:4]([OH:16])=[O:3])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69423048Ethyl 3-(4-fluorophenyl)-2,2-dimethylpropanoate

생성물 1

HCID 223502093-(4-Fluorophenyl)-2,2-dimethylpropanoic acid수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 3-(4-fluorophenyl)-2,2-dimethylpropionic acid ethyl ester (10.0 g, 44.6 mmol, see Part 1 of Example 25a) and a solution of sodium hydroxide (25 g) in water (110 mL) was heated at reflux for 18 h and cooled to room temperature. The solution was stirred on an ice bath and acidified with concentrated aqueous hydrochloric acid. The resulting precipitate was collected by filtration, washed with water and dried under vacuum. The residue was stirred with dichloromethane and filtered, and the filtrate was concentrated to provide an off-white solid (7.60 g, 87%).

후처리

  1. temperatureat reflux for 18 h
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried under vacuum
  5. stirringThe residue was stirred with dichloromethane
  6. filtrationfiltered
  7. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-cf126b75a27f4fce8171e2e2b442e4b3
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07291744B2

반응 노트

불러오는 중…