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Sodium hydride → tert-Butyl 4-cyano-4-(3-methoxyphenyl)piperidine-1-carboxylate

HRID 1592880
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HRID 1592880 반응식
[H-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH2:11][C:12]#[N:13])[CH:8]=[CH:9][CH:10]=1.Cl[CH2:15][CH2:16][N:17]([CH2:25][CH2:26]Cl)[C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21]>CS(C)=O.C1COCC1>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2([C:12]#[N:13])[CH2:26][CH2:25][N:17]([C:18]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:24])[CH2:16][CH2:15]2)[CH:8]=[CH:9][CH:10]=1
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참가 물질

6

반응물 3

HCID 24758Sodium hydrideHCID 88310(3-Methoxyphenyl)acetonitrileHCID 11230235N-BOC-N,N-Bis(2-chloroethyl)amine

생성물 1

HCID 49760266tert-Butyl 4-cyano-4-(3-methoxyphenyl)piperidine-1-carboxylate수율 87.9%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매2회
HCID 8028
Tetrahydrofuran
용매

실험 절차

This compound is prepared by the procedure described in step A of preparation 1.8, from 16.3 g of sodium hydride at a concentration of 60% in oil in 400 ml of DMSO, 30 g of 3-methoxyphenylacetonitrile in 150 ml of THF and 47 g of tert-butyl bis(2-chloroethyl)carbamate in 100 ml of DMSO. This gives 54 g of the expected product.

후처리

  1. customThis compound is prepared by the procedure

출처 및 근거

ORD 기록
ord-dca56bda4c174bc0b594391efec3d722
출처 데이터셋
uspto-grants-2007_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07294628B2

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