Hydrochloric Acid → 3-((3-Bromophenyl)thio)propanoic acid

HRID 1593031노트

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HRID 1593031 반응식
[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([O:13]CC)=[O:12])[CH:5]=[CH:6][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([S:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 62805311Ethyl 3-[(3-bromophenyl)thio]propanoate

생성물 1

HCID 186867493-((3-Bromophenyl)thio)propanoic acid수율 37.6%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
20 °C

실험 절차

A solution of ethyl 3-[(3-bromophenyl)thio]propanoate (1.15 g) in ethanol (5 ml) was treated with aqueous sodium hydroxide solution (2M, 5 ml) and the mixture was stirred at 20° C. for 15 h. The mixture was acidified with hydrochloric acid and the solution was extracted with ethyl acetate. The organic solution was washed with hydrochloric acid, brine, dried (MgSO4), and evaporated to give the title compound (390 mg) LCMS RT=3.19 min

후처리

  1. extractionthe solution was extracted with ethyl acetate
  2. washThe organic solution was washed with hydrochloric acid, brine
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-44c0eb05cb734f3f88b19ebbeb7929ba
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294650B2

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