Methyl acetoacetate → 1-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide

HRID 1593178노트

반응식

HRID 1593178 반응식
C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][C:20]([F:23])([F:22])[F:21])=O.[NH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]1[OH:32].[CH:33]1([NH2:39])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[CH:33]1([NH:39][C:3]([C:4]2[CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][C:20]([F:23])([F:22])[F:21])[N:24]([CH2:25][CH:26]3[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]3[OH:32])[C:5]=2[CH3:6])=[O:2])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

참가 물질

5

반응물 4

HCID 7757Methyl acetoacetateHCID 7965CyclohexylamineHCID 5338852-(Aminomethyl)cyclohexan-1-olHCID 27786842-(Trifluoromethoxy)phenacyl bromide

생성물 1

HCID 589989221-(2-Hydroxy-cyclohexylmethyl)-2-methyl-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide

실험 절차

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2-trifluoromethoxy-phenyl)-ethanone as compound of formula S, 2-aminomethyl-1-cyclohexanol as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 479.6 (M+H)+.

출처 및 근거

ORD 기록
ord-d45115ea0d30452c911d9e274f377d69
출처 데이터셋
uspto-grants-2007_11
특허 번호
US07294644B2

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