Dimethylformamide → Anthranilic acid, N-dimethylaminomethylene-, methyl ester
반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].P(Cl)(Cl)(Cl)=O.[OH-].[Na+].[CH3:19][N:20]([CH3:23])[CH:21]=O>ClCCl>[CH3:19][N:20]([CH:23]=[N:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([O:10][CH3:11])=[O:9])[CH3:21]참가 물질
6
실험 절차
To a stirred solution of 7.56 g of methyl anthranilate in 50 ml of dimethylformamide at 0° C. was added 5.6 ml of phosphorous oxychloride during 15 m. The mixture was heated at 55 for 45 m, cooled to 0, and diluted with dichloromethane. The mixture was basified at 0° C. by slow addition of cold 1N NaOH to pH 9. The dichloromethane layer was separated, washed with water, dried and concentrated to an oil.
후처리
- temperatureThe mixture was heated at 55 for 45 m
- temperaturecooled to 0
- customThe dichloromethane layer was separated
- washwashed with water
- customdried
- concentrationconcentrated to an oil
출처 및 근거
- ORD 기록
- ord-e8a60b800d404bacb268e5c3beefec69
- 출처 데이터셋
- uspto-grants-2001_09
- 특허 번호
- US06288082B1
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