Phenylpropanolamine → (1S,2R)-2-amino-1-phenylpropan-1-ol

HRID 1595956

반응식

HRID 1595956 반응식
[CH3:1][C@H:2]([NH2:11])[C@H:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[BH4-].[Na+]>C(O)C>[CH3:1][C@@H:2]([NH2:11])[C@@H:3]([OH:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 10297PhenylpropanolamineHCID 4311764Sodium borohydride

생성물 1

HCID 26934(1S,2R)-2-amino-1-phenylpropan-1-ol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

As shown in the scheme above, (1R, 2S)-(−)- norephedrine is reacted with an optionally substituted benzaldehyde by refluxing in ethanol, and reducing the product of that reaction with sodium borohydride at ambient temperature to produce the desired norephedrine derivative compound.

출처 및 근거

ORD 기록
ord-b28c151d057f4f0bbcfc10c69ab8201e
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288233B1

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