1-Chloro-4-morpholin-4-yl-2-naphthol → 4-Morpholino-2-naphthol

HRID 1596668

반응식

HRID 1596668 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[CH:4][C:3]=1[OH:18]>[OH-].[Na+].C(O)C.[Pd]>[O:15]1[CH2:14][CH2:13][N:12]([C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH:2]=[C:3]([OH:18])[CH:4]=2)[CH2:17][CH2:16]1

참가 물질

5

반응물 1

HCID 6096921-Chloro-4-morpholin-4-yl-2-naphthol

생성물 1

HCID 109880424-Morpholino-2-naphthol수율 77.8%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

in a 0.3 l steel autoclave, 10.5 g of 1-chloro-4-morpholino-2-naphthol in 150 ml of sodium hydroxide (2N) and 30 ml of ethanol are maintained under a pressure of 3 bar and at 35° C. in the presence of 3 g of palladium on charcoal (5%) for 7 hours. The solution is then filtered to remove the catalyst. The aqueous phase is then acidified with acetic acid and then filtered. The precipitate is washed with water and then dried. 7.1 g of 4-morpholino-2-naphthol are thus obtained.

후처리

  1. filtrationThe solution is then filtered
  2. customto remove the catalyst
  3. filtrationfiltered
  4. washThe precipitate is washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-9097480114864321971c9a53acc09a4f
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06291561B1

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