Carbon tetrabromide → 4-(Bromomethyl)-2-fluoro-1-(methylsulfanyl)benzene
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:10]O)[CH:5]=[CH:6][C:7]=1[S:8][CH3:9].C(Br)(Br)(Br)[Br:13].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:13][CH2:10][C:4]1[CH:5]=[CH:6][C:7]([S:8][CH3:9])=[C:2]([F:1])[CH:3]=1참가 물질
5
실험 절차
The mixture of [3-fluoro-4-(methylsulfanyl)phenyl]methanol (9.00 g, 52.26 mmol) and carbon tetrabromide (19.06 g, 57.49 mmol) in CH2Cl2 (200 mL) was added triphenylphosphine (15.08 g, 57.49 mmol) at 0° C. After 1 hour, the mixture was concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/10) to provide the subtitle compound (12.16 g, 94% yield) as an oil.
후처리
- concentrationthe mixture was concentrated in vacuo
- customThe residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/10)
출처 및 근거
- ORD 기록
- ord-8dab1d5fc8d34760b8318aa6f0a2fbd4
- 출처 데이터셋
- uspto-grants-2001_09
- 특허 번호
- US06294558B1
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