Lithium Hydroxide → HCID 178489168, 화합물

HRID 1601442노트

반응식

HRID 1601442 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:17][N:16]=[N:15][N:14]=2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Li+].O1CCCC1.O>Cl.ClCCl>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([C:13]2[NH:14][N:15]=[N:16][N:17]=2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

참가 물질

6

반응물 3

HCID 3939Lithium HydroxideHCID 21881883Oxolane--water (1/1)HCID 178497409HCID 178497409, 화합물

생성물 1

HCID 178489168HCID 178489168, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 6344Dichloromethane용매

실험 절차

Combine methyl 2-methoxy-5-(1H-tetrazol-5-yl)benzoate (1 mmol) and lithium hydroxide (1.1 mmol) in 1/1 tetrahydrofuran/water (5 mL). After 24 hours, dilute the reaction mixture with a 0.5M aqueous hydrochloric acid solution and dichloromethane. Separate the layers and extract the aqueous layer three times with dichloromethane. Combine the organic layers, dry over MgSO4, filter, and evaporate in vacuo to give 2-methoxy-5-(1H-tetrazol-5-yl)benzoic acid.

후처리

  1. customSeparate the layers
  2. extractionextract the aqueous layer three times with dichloromethane
  3. dry with materialdry over MgSO4
  4. filtrationfilter
  5. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-d5261fbe54fb487eb84e69f11befb6f8
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977139

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