Propylene Oxide → Gadoteridol

HRID 1601642

반응식

HRID 1601642 반응식
[Na+].[N:2]1([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3]1.[Na+].[Na+].[CH2:28]1[O:31][CH:29]1[CH3:30].[Gd:32]>>[CH3:28][CH:29]([OH:31])[CH2:30][N:11]1[CH2:10][CH2:9][N:8]([CH2:14][C:15]([O-:17])=[O:16])[CH2:7][CH2:6][N:5]([CH2:18][C:19]([O-:21])=[O:20])[CH2:4][CH2:3][N:2]([CH2:22][C:23]([O-:25])=[O:24])[CH2:13][CH2:12]1.[Gd+3:32]

참가 물질

4

반응물 3

HCID 6378Propylene OxideHCID 23982GadoliniumHCID 108625271,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid trisodium salt

생성물 1

HCID 60714Gadoteridol

실험 절차

The solution of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid sodium salt is directly reacted, as described in EP 292689, with propylene oxide to give the alkylated product, which can easily be complexed with gadolinium to give the final Gadoteridol.

후처리

  1. customto give the alkylated product, which

출처 및 근거

ORD 기록
ord-b8c2b92330a14aa49e05781c3b6833d4
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05977353

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