Sodium Hydroxide → 1-Quinolin-6-yl-ethanone oxime

HRID 16024

반응식

HRID 16024 반응식
Cl.[NH2:2][OH:3].[OH-].[Na+].[N:6]1[C:15]2[C:10](=[CH:11][C:12]([C:16](=O)[CH3:17])=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1>CCO>[N:6]1[C:15]2[C:10](=[CH:11][C:12]([C:16](=[N:2][OH:3])[CH3:17])=[CH:13][CH:14]=2)[CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 2585591-(Quinolin-6-yl)ethan-1-oneHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 722593651-Quinolin-6-yl-ethanone oxime수율 99%

시약·촉매·용매 1

HCID 702Ethanol용매3회

실험 절차

To a suspension of hydroxylamine hydrochloride in EtOH (150 mL) was added a suspension of NaOH (2.4 g, 59.7 mmol) in EtOH (25 mL). The reaction mixture was stirred at ambient temperature for 15 minutes. The precipitated sodium hydrochloride was filtered off. A solution of 1-quinolin-6-yl-ethanone (9.3 g, 54.25 mmol) in EtOH (150 mL) was added. The reaction solution was stirred for 16 hours at ambient temperature. EtOH was removed in vacuum to give 1-quinolin-6-yl-ethanone oxime (10.1 g, >99% yield).

후처리

  1. additionwas added
  2. filtrationThe precipitated sodium hydrochloride was filtered off
  3. stirringThe reaction solution was stirred for 16 hours at ambient temperature
  4. customEtOH was removed in vacuum

출처 및 근거

ORD 기록
ord-816d608857b34abfbff324ae548cd0f4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732604B2

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