Hydrochloric Acid → 4-(3-Carboxypropyl)Amino-6,7,8-Trimethoxyquinazoline

HRID 1603525노트

반응식

HRID 1603525 반응식
[OH-].[Na+].C([O:5][C:6]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:21]2[C:16](=[C:17]([O:26][CH3:27])[C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)=[O:7])C.C(O)C.Cl>O1CCCC1>[C:6]([CH2:8][CH2:9][CH2:10][NH:11][C:12]1[C:21]2[C:16](=[C:17]([O:26][CH3:27])[C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1)([OH:7])=[O:5]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 97984504-(3-Ethoxycarbonylpropyl)Amino-6,7,8-Trimethoxyquinazoline

생성물 1

HCID 98619074-(3-Carboxypropyl)Amino-6,7,8-Trimethoxyquinazoline수율 744%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5 ml of a 1N aqueous solution of sodium hydroxide is added to a solution of 0.52 g (1.5 mmol) of the 4-(3-ethoxycarbonylpropyl)amino-6,7,8-trimethoxyquinazoline obtained in Example 1 in tetrahydrofuran (5 ml)/ethanol (5 ml), followed by stirring at room temperature one whole day and night. The reaction liquid is neutralized with 5 ml of 1N hydrochloric acid, and then concentrated under reduced pressure. The crystals thus precipitated are recovered by filtration, washed with water, and dried with air. Thus, 0.36 g (yield 744%) of a pale-yellow crystal is obtained.

후처리

  1. customThe reaction liquid
  2. concentrationconcentrated under reduced pressure
  3. customThe crystals thus precipitated
  4. filtrationare recovered by filtration
  5. washwashed with water
  6. customdried with air

출처 및 근거

ORD 기록
ord-0a80c348d3af4ddcb017380d41b1652c
출처 데이터셋
uspto-grants-1999_11
특허 번호
US05990117

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