Pyridine → 1-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine

HRID 16058

반응식

HRID 16058 반응식
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[C:16]1(C)[C:17]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=1.N1C=CC=C[CH:28]=1>C(Cl)(Cl)Cl>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][S:22]([C:17]2[CH:16]=[CH:21][C:20]([CH3:28])=[CH:19][CH:18]=2)(=[O:23])=[O:24])[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8623o-Toluenesulfonyl chlorideHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

생성물 1

HCID 106428511-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A solution of N-Boc-4-piperidinemethanol, 5.0 g (23.2 mmol) in chloroform, 50 mL, was prepared. Toluene sulfonyl chloride, 5.75 g (30.2 mmol), in 5.6 mL of pyridine (69.6 mmol) was added. The solution was stirred under nitrogen allowed to stir for 24 hours. Standard workup and chromatographic purification provided the title compound. Yield 6.0 g

후처리

  1. stirringto stir for 24 hours
  2. customStandard workup and chromatographic purification

출처 및 근거

ORD 기록
ord-c7699937794840df9e4605140d7e4fc6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737127B2

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