Sodium Hydroxide → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

HRID 1608211노트

반응식

HRID 1608211 반응식
C([NH:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH2:10][CH2:9][N:8]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:7]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10683176N-({4-[(4-Fluorophenyl)methyl]morpholin-2-yl}methyl)acetamide

생성물 1

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine (3.0 g) in 10% hydrochloric acid (50 ml) is refluxed with stirring for 4 hours. The reaction mixture is adjusted to pH 11 with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium chloride solution, and dried over magnesium sulfate. Removal of the solvent under reduced pressure gives the title compound as an oil.

후처리

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. customRemoval of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-5294a44b751645709e9b69ea735d3844
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

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