Sodium Hydroxide → HCID 10037975, 화합물

HRID 1608228노트

반응식

HRID 1608228 반응식
C([NH:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1)(=O)C.[OH-].[Na+]>Cl>[NH2:4][CH2:5][CH:6]1[O:11][CH:10]([CH3:12])[CH2:9][N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[Cl:20])[CH2:7]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 198486042-Acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine

생성물 1

HCID 10037975HCID 10037975, 화합물수율 85.4%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2-acetylaminomethyl-4-(2-chlorobenzyl)-6-methylmorpholine (3.0 g) in 10% hydrochloric acid (60 ml) is refluxed with stirring for 2 hours. The reaction mixture is basified with aqueous sodium hydroxide solution and extracted with chloroform. The organic layer is washed successively with water and saturated aqueous sodium choride solution, and dried over magnesium sulfate. The solvent is distilled off under reduced pressure to give the title compound (2.2 g) as an oil.

후처리

  1. extractionextracted with chloroform
  2. washThe organic layer is washed successively with water and saturated aqueous sodium choride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationThe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-d831fa94c3bb4e4887f42133d93c4b5a
출처 데이터셋
uspto-grants-1989_09
특허 번호
US04870074

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