Hydrochloric Acid → HCID 178447286, 화합물

HRID 1609202노트

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HRID 1609202 반응식
[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH2:26][C:27]([CH2:35][CH3:36])([CH2:33][CH3:34])[C:28]([O:30]CC)=[O:29])[C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=2)=[N:4][N:3]=[N:2]1.[OH-].[Na+].Cl.C(Cl)Cl.CO>C(O)C>[C:28]([C:27]([CH2:35][CH3:36])([CH2:33][CH3:34])[CH2:26][N:19]([C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])[CH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[C:5]2[NH:1][N:2]=[N:3][N:4]=2)=[CH:17][CH:16]=1)([OH:30])=[O:29]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21226129Dichloromethane methanolHCID 178447287HCID 178447287, 화합물

생성물 1

HCID 178447286HCID 178447286, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.146 g of ethyl N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-2-aminomethyl-2-ethylbutyrate are dissolved in 10 ml of ethanol, treated with 4.66 ml of 2N NaOH solution and heated to reflux for 20 hours. After cooling to room temperature and addition of 4.66 ml of 2N hydrochloric acid, the mixture is evaporated. The product is isolated by chromatography on silica gel 60 (40-63 μm) using CH2Cl2 -MeOH 80:20, Rf =0.38 (system N8). MS (FAB):m/e 486 (M+ +Na), 502 (M+ +K).

후처리

  1. temperatureheated
  2. temperatureto reflux for 20 hours
  3. customthe mixture is evaporated
  4. customThe product is isolated by chromatography on silica gel 60 (40-63 μm)

출처 및 근거

ORD 기록
ord-7bbeb25c82b14a078faf62d75068e9ec
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399578

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