Hydrochloric Acid → Isopropyl 1-methyl-3-indoleacetimidate hydrochloride

HRID 1609389

반응식

HRID 1609389 반응식
[ClH:1].[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13]#[N:14])=[CH:4]1.[CH:15]([OH:18])([CH3:17])[CH3:16]>>[ClH:1].[CH3:2][N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13](=[NH:14])[O:18][CH:15]([CH3:17])[CH3:16])=[CH:4]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 106547202-(1-methyl-1H-indol-3-yl)acetonitrile

생성물 1

HCID 22907276Isopropyl 1-methyl-3-indoleacetimidate hydrochloride수율 44%

실험 절차

Hydrogen chloride was bubbled through a stirred solution of 7.5 g (44 mmol) of 1-methylindole-3-acetonitrile in 100ml of dry isopropanol at room temperature. After 4 hours, the solvent was removed under reduced pressure and the residue was triturated with diethyl ether to give 5.17 g (44%) of isopropyl 1-methyl-3-indoleacetimidate hydrochloride as a white solid of melting point 133° C.

후처리

  1. customthe solvent was removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-968189737b3e40409f7af5ed50844dcc
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399712

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