Hydrochloric Acid → ethyl (2RS,3RS)-3-(4-fluorophenyl)-3-hydroxy-2-[3-(isopropyloxy)benzyl]propanoate

HRID 1610644노트

반응식

HRID 1610644 반응식
[BH4-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:28])[CH:11]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH:25]([CH3:27])[CH3:26])[CH:19]=2)[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:6][CH:5]=1.Cl>C(OCC)C.[Cl-].[Zn+2].[Cl-]>[F:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([OH:28])[CH:11]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH:25]([CH3:27])[CH3:26])[CH:19]=2)[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 22262205Ethyl 3-(4-fluorophenyl)-3-oxo-2-[3-(isopropyloxy)benzyl]propanoate

생성물 1

HCID 86593286ethyl (2RS,3RS)-3-(4-fluorophenyl)-3-hydroxy-2-[3-(isopropyloxy)benzyl]propanoate

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 3283Diethyl Ether용매2회

실험 절차

To a suspension of anhydrous zinc chloride (9.12 g, 67.0 mmol) in diethyl ether (100 ml) was added sodium borohydride (5.07 g, 134 mmol) by small portions, and the mixture was stirred for 2 hrs. Insoluble material was filtered off, and washed with diethyl ether. The filtrate was ice-cooled, and to the filtrate was added a solution of ethyl 3-(4-fluorophenyl)-3-oxo-2-[3-(isopropyloxy)benzyl]propanoate (12.0 g, 33.5 mmol) in diethyl ether (20 ml). The mixture was stirred at room temperature for 2 hrs. and ice-cooled again. 1N Hydrochloric acid was added to stop the reaction. The mixture was washed with water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel chromatography(hexane:ethyl acetate=10:1) to give the objective substance (10 g, 83%) as a colorless oil

후처리

  1. filtrationInsoluble material was filtered off
  2. washwashed with diethyl ether
  3. temperaturecooled
  4. stirringThe mixture was stirred at room temperature for 2 hrs
  5. temperatureand ice-cooled again
  6. customthe reaction
  7. washThe mixture was washed with water
  8. dry with materialdried over anhydrous magnesium sulfate
  9. customevaporated under reduced pressure
  10. customThe residue was purified by silica gel chromatography(hexane:ethyl acetate=10:1)
  11. customto give the objective substance (10 g, 83%) as a colorless oil

출처 및 근거

ORD 기록
ord-1cba63e3550149b583f590d0fee172e3
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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