Hydroquinone → Phenol, 4-(2-methylbutoxy)-

HRID 1612586

반응식

HRID 1612586 반응식
[C:1]1([CH3:16])[CH:6]=CC(S(OCC(C)CC)(=O)=O)=[CH:3][CH:2]=1.[C:17]1([CH:24]=[CH:23][C:21]([OH:22])=[CH:20][CH:19]=1)[OH:18].[OH-].[Na+]>O.C(O)CCC>[CH3:6][CH:1]([CH2:2][CH3:3])[CH2:16][O:18][C:17]1[CH:24]=[CH:23][C:21]([OH:22])=[CH:20][CH:19]=1

참가 물질

6

반응물 3

HCID 785HydroquinoneHCID 14798Sodium HydroxideHCID 3011991-Butanol, 2-methyl-, 1-(4-methylbenzenesulfonate)

생성물 1

HCID 106720Phenol, 4-(2-methylbutoxy)-수율 72%

시약·촉매·용매 2

HCID 2631-Butanol용매2회HCID 962Water용매2회

반응 조건

온도
120 °C

실험 절차

Into a n-butanol suspension containing 37 mmol (9.0 g) of 2-methylbutyl p-toluenesufonate prepared by tosylating S-(-)-2-methylbutanol and 74 mmol (8.2 g) of hydroquinone, added dropwise was a solution of 50 mmol (2.1 g) of sodium hydroxide dissolved in a solvent mixture of 3 ml of water and 10 ml of n-butanol. After conclusion of the dropping, the mixture was then stirred for 8 hours at 120° C. After addition of water, the reaction solution was extracted with ether, and the extracted solution was dried and concentrated. The concentrate was purified by column chromatography, to obtain 4.8 g of the objective ether compound (Yield: 72%)

후처리

  1. customprepared
  2. additionadded dropwise
  3. extractionthe reaction solution was extracted with ether
  4. customthe extracted solution was dried
  5. concentrationconcentrated
  6. customThe concentrate was purified by column chromatography

출처 및 근거

ORD 기록
ord-207c851bb48e4a778e62958d6f46b8d8
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05190686

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