Quinolinic Acid → 2,3-Piperidinedicarboxylic acid

HRID 1614044

반응식

HRID 1614044 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]([OH:9])=[O:8])[C:2]=1[C:10]([OH:12])=[O:11]>[OH-].[Na+].[Ni].[Al]>[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]([OH:9])=[O:8])[CH:2]1[C:10]([OH:12])=[O:11]

참가 물질

4

반응물 1

HCID 1066Quinolinic Acid

생성물 1

HCID 12262,3-Piperidinedicarboxylic acid

시약·촉매·용매 2

HCID 6336846Nickel aluminide촉매HCID 14798Sodium Hydroxide용매

실험 절차

Dissolve pyridine-2,3-dicarboxylic acid (20 g, 120 mmol) in 0.5N aqueous sodium hydroxide (900 mL). Add nickel/aluminum powder (45 g) in portions over 3 hours. Stir for 4 days, filter off the catalyst to yield the title compound in clear solution. The resulting free amine is not isolated.

후처리

  1. filtrationfilter off the catalyst

출처 및 근거

ORD 기록
ord-4ae1b8d90aed453fa680cafe417b52af
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194430

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