N-Hydroxyphthalimide → 2-(Cyclopent-3-enyloxy)isoindoline-1,3-dione

HRID 1614067노트

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HRID 1614067 반응식
[CH:1]1([OH:6])[CH2:5][CH:4]=[CH:3][CH2:2]1.O[N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O>O1CCCC1>[CH:1]1([O:6][N:8]2[C:9](=[O:18])[C:10]3=[CH:17][CH:16]=[CH:15][CH:14]=[C:11]3[C:12]2=[O:13])[CH2:5][CH:4]=[CH:3][CH2:2]1

참가 물질

6

반응물 4

HCID 10665N-HydroxyphthalimideHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 2814783-Cyclopenten-1-ol

생성물 1

HCID 197740932-(Cyclopent-3-enyloxy)isoindoline-1,3-dione수율 61.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
45 °C

실험 절차

To a solution of 3-cyclopenten-1-ol (15.3 g), N-hydroxyphthalimide (29.7 g) and triphenylphosphine (47.7 g) in tetrahydrofuran (250 ml) was added diethyl azodicarboxylate (31.7 g) at 40° to 50° C. After stirring at 45° C. for 2 hours, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The separated organic layer was washed with 5% aqueous solution of sodium bicarbonate, brine, successively and dried over magnesium sulfate. The solvent was evaporated in vacuo, and the residual oil was subjected to column chromatography on silica gel. The desired product was eluted with 15% ethyl acetate in n-hexane to give N-(3-cyclopenten-1-yloxy)phthalimide (25.6 g).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe separated organic layer was washed with 5% aqueous solution of sodium bicarbonate, brine
  3. dry with materialsuccessively and dried over magnesium sulfate
  4. customThe solvent was evaporated in vacuo
  5. washThe desired product was eluted with 15% ethyl acetate in n-hexane

출처 및 근거

ORD 기록
ord-149b2c5b5ccb41d99ccc5a2f9791eeaa
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194432

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