Hydrochloric Acid → 1-Propyl-1,3-diazinane-2,4,6-trione

HRID 16145

반응식

HRID 16145 반응식
[Na].[C:2]([O:10]CC)(=O)[CH2:3][C:4]([O:6]CC)=O.[CH2:13]([NH:16][C:17]([NH2:19])=[O:18])[CH2:14][CH3:15].Cl>O.C(O)C>[CH2:13]([N:16]1[C:2](=[O:10])[CH2:3][C:4](=[O:6])[NH:19][C:17]1=[O:18])[CH2:14][CH3:15]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 7761Diethyl MalonateHCID 12303PropylureaHCID 5360545Sodium2회

생성물 1

HCID 2855681-Propyl-1,3-diazinane-2,4,6-trione

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Metallic sodium (2.6 g, 113 mmol) is added to ethanol (60 ml). The mixture is stirred until the sodium has completely finished reacting. Diethyl malonate (116 ml, 105 mmol) and n-propylurea (10 g, 98 mmol) are then added and the mixture is stirred under reflux for 5 h. After conc. HCl (5 ml) and hot water (45 ml) have been added, the mixture is filtered and the filtrate is concentrated in vacuo. Ethanol is added to the residue and the mixture is stirred. The solid is filtered off with suction and dried.

후처리

  1. temperatureunder reflux for 5 h
  2. filtrationthe mixture is filtered
  3. concentrationthe filtrate is concentrated in vacuo
  4. additionEthanol is added to the residue
  5. stirringthe mixture is stirred
  6. filtrationThe solid is filtered off with suction
  7. customdried

출처 및 근거

ORD 기록
ord-a5c35d0dd7fe4a1aa842846ec4e1bb61
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737144B2

연결된 노트

불러오는 중…