Hydrogen Bromide → 5-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone

HRID 1614548노트

반응식

HRID 1614548 반응식
Br.[NH2:2][C:3]1[C:4]([Br:16])=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH3:14])([CH3:13])[C:7](=[O:15])[NH:6]2.[NH:17]1[CH2:21][CH2:20][N:19]=[C:18]1S(O)(=O)=O.Br>C(O)C(C)C>[Br:16][C:4]1[C:3]([NH:2][C:18]2[NH:19][CH2:20][CH2:21][N:17]=2)=[CH:12][CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:15])[C:8]([CH3:13])([CH3:14])[NH:9]2

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 2745614,5-dihydro-1H-imidazole-2-sulfonic acidHCID 199364056-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

생성물 1

HCID 152257155-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone

시약·촉매·용매 1

HCID 6560Isobutanol용매

실험 절차

A mixture of 6-amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4H) - quinoxalinone hydrobromide (479 mg, 1 mmol) and 2-imidazoline-2-sulfonic acid (224 mg, 1.5 mmol) in isobutanol (5 ml) is heated at reflux until the starting hydrobromide material is consumed. The solvent is removed in vacuo and the residue chromatographed on silica gel with CHCl3 : CH3OH saturated with NH3 (g) elution to yield the title compound.

후처리

  1. temperatureis heated
  2. customis consumed
  3. customThe solvent is removed in vacuo
  4. customthe residue chromatographed on silica gel with CHCl3
  5. washCH3OH saturated with NH3 (g) elution

출처 및 근거

ORD 기록
ord-5e284c4625ad4d8ca1c9e107b11db3fd
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05198442

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