Diisopropylethylamine → HCID 67995869, 화합물

반응식

Cl[C:2](Cl)([O:4]C(=O)OC(Cl)(Cl)Cl)Cl.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([C@@H:20]([NH:22][CH2:23][CH2:24][C:25]([OH:32])([CH2:29][CH:30]=[CH2:31])[CH2:26][CH:27]=[CH2:28])[CH3:21])=[CH:16][CH:15]=1.C(N(C(C)C)C(C)C)C>ClCCl>[CH2:29]([C:25]1([CH2:26][CH:27]=[CH2:28])[O:32][C:2](=[O:4])[N:22]([C@H:20]([C:17]2[CH:16]=[CH:15][C:14]([Br:13])=[CH:19][CH:18]=2)[CH3:21])[CH2:23][CH2:24]1)[CH:30]=[CH2:31]

참가 물질

실험 절차

Triphosgene (6.90 g) is added to a solution of 4-{2-[(S)-1-(4-bromo-phenyl)-ethylamino]-ethyl}-hepta-1,6-dien-4-ol (7.86 g) and ethyl-diisopropyl-amine (4 mL) in dichloromethane (150 mL) chilled in an ice bath. The cooling bath is removed and the solution is stirred at room temperature overnight. Water is added and the organic phase is then separated. The organic phase is dried (Na2SO4) and concentrated to give the crude title compound that is used without further purification. Yield: 8.65 g (ca. 90% pure); LC (method 1): tR=4.03 min; Mass spectrum (ESI+): m/z=364/366 (Br) [M+H]+.