Hydrazine hydrate (1:1) → 8-Amino-7-(methylamino)quinoline
반응식
[CH3:1][NH:2][C:3]1[C:12]([N+:13]([O-])=O)=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.O.NN>CO.[Ni]>[CH3:1][NH:2][C:3]1[C:12]([NH2:13])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1참가 물질
5
실험 절차
To a solution of N-methyl-8-nitroquinolin-7-amine (1.6 g, 7.9 mmol) in MeOH (25 mL) was added hydrazine hydrate (2.25 g, 455 mmol) and Raney Ni (8 drops). The mixture was stirred at room temperature for 20 minutes. The catalyst was removed by filtration and the filtrate was concentrated to give N7-methylquinoline-7,8-diamine as a yellow solid (1.2 g, yield 80%). ESI MS: m/z 174 [M+H]+.
후처리
- customThe catalyst was removed by filtration
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-e2d6092f1f964319a6cd5877d7dfe00c
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765760B2
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