Hydrazine hydrate (1:1) → 6-Quinoxalinamine

HRID 1615639

반응식

HRID 1615639 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][CH:8]=[N:7]2)([O-])=O.O.NN>CO.[Ni]>[N:10]1[C:11]2[C:6](=[CH:5][C:4]([NH2:1])=[CH:13][CH:12]=2)[N:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 96029Quinoxaline, 6-nitro-

생성물 1

HCID 2378596-Quinoxalinamine수율 99.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

To a solution of 6-nitroquinoxaline (17.0 g, 0.097 mol) in MeOH (500 mL) was added hydrazine hydrate (19.4 g, 0.39 mol) and Raney Ni (2.0 g). The mixture was stirred at room temperature for 1 h. The mixture was then filtered, and the filtrate was concentrated under reduce pressure to give quinoxalin-6-amine as a yellow solid (14.0 g, yield 99%). ESI MS: m/z 146.1 [M+H]+.

후처리

  1. filtrationThe mixture was then filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9cdf1da6eb244c898404521920a9f67c
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765760B2

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