Water → HCID 68089365, 화합물

HRID 1615641노트

반응식

HRID 1615641 반응식
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:14])[CH3:13])=[CH:8][CH:9]=2)[N:4]=[CH:3][CH:2]=1.[H-].[Na+].I[CH3:18].O>C1COCC1>[CH3:18][N:11]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[N:1]=[CH:2][CH:3]=[N:4]2)[C:12](=[O:14])[CH3:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 23273816HCID 23273816, 화합물

생성물 1

HCID 68089365HCID 68089365, 화합물수율 93%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of N-(quinoxalin-6-yl)acetamide (8.0 g, 0.043 mol) in THF (120 mL) was added sodium hydride (60% wt in mineral oil, 3.42 g, 0.086 mol). The mixture was stirred at room temperature for 10 min. Then iodomethane (7.28 g, 0.051 mol) was added. The mixture was stirred at room temperature for 2 h. Water (60 mL) was added carefully. The mixture was extracted with EtOAc (3×150 mL). The extracts were dried over sodium sulfate, concentrated to give N-methyl-N-(quinoxalin-6-yl)acetamide as a brown solid (8.04 g, yield 93%). ESI MS: m/z 202.1 [M+H]+.

후처리

  1. stirringThe mixture was stirred at room temperature for 2 h
  2. extractionThe mixture was extracted with EtOAc (3×150 mL)
  3. dry with materialThe extracts were dried over sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a104ce3e2d114e70a4566d385232435e
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765760B2

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