Hydrochloric Acid → HCID 68491626, 화합물

HRID 1616541노트

반응식

HRID 1616541 반응식
[OH-].[Na+].C[O:4][C:5](=[O:23])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[O:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:15][N:16]=1.Cl>O.CO>[C:17]1([C:14]2[O:13][C:12]([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][C:5]([OH:23])=[O:4])=[N:16][CH:15]=2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59167750Methyl 7-(5-phenyl-1,3-oxazol-2-yl)heptanoate

생성물 1

HCID 68491626HCID 68491626, 화합물수율 85.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Add a solution of sodium hydroxide (1.80 g, 45.0 mmol) in water (30 mL) to a solution of 7-(5-phenyloxazol-2-yl)heptanoic acid methyl ester (9.0 g, 31.3 mmol) in methanol (30 mL) at room temperature and stir the mixture for 4 hours. Adjust the pH of the mixture to 2 with 1 N HCl and extract with ethyl acetate (500 mL). Wash the combined organic layers with water (3×100 mL), dry over sodium sulfate and remove the solvent under reduced pressure. Crystallize the residue from ethyl acetate/hexanes to afford 7-(5-phenyloxazol-2-yl)heptanoic acid (7.3 g, 85%): APCI mass spectrum m/z 272 [C16H19NO3—H]−.

후처리

  1. extractionextract with ethyl acetate (500 mL)
  2. washWash the combined organic layers with water (3×100 mL)
  3. dry with materialdry over sodium sulfate
  4. customremove the solvent under reduced pressure
  5. customCrystallize the residue from ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-7ef27399b6d148ba8c975d62024e626b
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765796B2

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