Sodium hydride → 8-[4-(2-Isopropoxyphenyl)imidazol-1-yl]octanoic acid methyl ester

HRID 1616561노트

반응식

HRID 1616561 반응식
[H-].[Na+].[CH:3]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]1[N:14]=[CH:15][NH:16][CH:17]=1)([CH3:5])[CH3:4].[CH3:18][O:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]Br>C1COCC1.[I-].C([N+](CCCC)(CCCC)CCCC)CCC.O>[CH3:18][O:19][C:20](=[O:29])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][N:16]1[CH:17]=[C:13]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][CH:3]([CH3:5])[CH3:4])[N:14]=[CH:15]1

참가 물질

7

반응물 3

HCID 24758Sodium hydrideHCID 11107373Methyl 8-bromooctanoateHCID 1784582854-[2-(propan-2-yloxy)phenyl]-1H-imidazole

생성물 1

HCID 591678008-[4-(2-Isopropoxyphenyl)imidazol-1-yl]octanoic acid methyl ester수율 57.6%

시약·촉매·용매 3

HCID 67553Tetrabutylammonium Iodide촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Add sodium hydride (1.82 g, 38 mmol) to a suspension of 4-(2-isopropoxyphenyl)-1H-imidazole (5.01 g, 25 mmol) in THF (125 mL) at 0° C. under nitrogen, and warm the mixture to room temperature and stir for 1 hour. Cool the mixture to 0° C. and add 8-bromooctanoic acid methyl ester (5.98 g, 25 mmol) and tetra-n-butylammonium iodide (0.55 g, 1.5 mmol) and warm the mixture to room temperature to stir for 8 hours. Dilute the mixture with water (20 mL) and remove the solvent under reduced pressure. Dilute the residue with ethyl acetate (300 mL), wash with water (100 mL) and brine (100 mL), dry over sodium sulfate, and remove the solvent under reduced pressure to provide 8-[4-(2-isopropoxyphenyl)imidazol-1-yl]octanoic acid methyl ester (5.16 g, 57%), which is used in the next step without further purification.

후처리

  1. temperatureCool the mixture to 0° C.
  2. temperaturewarm the mixture to room temperature
  3. stirringto stir for 8 hours
  4. customremove the solvent under reduced pressure
  5. additionDilute the residue with ethyl acetate (300 mL)
  6. washwash with water (100 mL) and brine (100 mL)
  7. dry with materialdry over sodium sulfate
  8. customremove the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-35afd06486c941cd8b59766b9aa1429a
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765796B2

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