Azobisisobutyronitrile → Benzoic acid, 3-(bromomethyl)-4-fluoro-, methyl ester
반응식
C1C(=O)N([Br:8])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C.[F:21][C:22]1[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=1[CH3:32]>CCOC(C)=O>[Br:8][CH2:32][C:23]1[CH:24]=[C:25]([CH:30]=[CH:31][C:22]=1[F:21])[C:26]([O:28][CH3:29])=[O:27]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
NBS (14.60 g) and AIBN (2.89 g) were added to a solution of the product from step (i) (9.85 g) in EtOAc (200 mL). The resulting mixture was stirred at 80° C. for 20 h. After cooling the mixture was washed with sat. sodium thiosulphate, brine, dried, filtered and the solvent removed. The crude product was purified using chromatography, to give the subtitle compound, 5.30 g.
후처리
- temperatureAfter cooling the mixture
- washwas washed with sat. sodium thiosulphate, brine
- customdried
- filtrationfiltered
- customthe solvent removed
- customThe crude product was purified
출처 및 근거
- ORD 기록
- ord-c5dd67bb22234be4aea0355aa8eafc20
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765939B2
반응 노트
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