Hydrochloric Acid → 2-(4-Cyclopropylpiperazin-1-yl)benzothiazol-6-ylamine

HRID 1619257노트

반응식

HRID 1619257 반응식
[CH:1]1([N:4]2[CH2:9][CH2:8][N:7]([C:10]3[S:11][C:12]4[CH:18]=[C:17]([NH:19]C(=O)C)[CH:16]=[CH:15][C:13]=4[N:14]=3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.Cl.[OH-].[Na+]>CCO>[CH:1]1([N:4]2[CH2:5][CH2:6][N:7]([C:10]3[S:11][C:12]4[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=4[N:14]=3)[CH2:8][CH2:9]2)[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 23728857N-[2-(4-cyclopropylpiperazin-1-yl)benzothiazol-6-yl]acetamide

생성물 1

HCID 595888042-(4-Cyclopropylpiperazin-1-yl)benzothiazol-6-ylamine수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of N-[2-(4-cyclopropylpiperazin-1-yl)benzothiazol-6-yl]-acetamide (679 mg, 2.15 mmol) in EtOH (36 mL) was added concentrated hydrochloric acid (7.2 mL). The mixture was heated at reflux for 2 h. After cooling, the mixture was neutralized with 15% sodium hydroxide. The volatiles were removed under reduced pressure and the residue was dissolved in methanol (10 mL). The mixture was filtered and the filtrate was concentrated in vacuo to give 512 mg (87%) of 2-(4-cyclopropylpiperazin-1-yl)benzothiazol-6-ylamine.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 2 h
  3. temperatureAfter cooling
  4. customThe volatiles were removed under reduced pressure
  5. dissolutionthe residue was dissolved in methanol (10 mL)
  6. filtrationThe mixture was filtered
  7. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-0416961939c14510bf6bae50fdc20221
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08772285B2

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